Borvo

Description

Borvo is a single-gene anti-phage system that was identified through bioinformatic prediction and experimental validation (N/A) .

Molecular mechanisms

Mutations in the phage DNA polymerase can allow phages to escape Borvo defense, indicating that it could be the trigger of the system (N/A) . Borvo is a suspected abortive infection (N/A) . However, as far as we are aware, the precise molecular mechanism of Borvo is unknown.

Example of genomic structure

The Borvo is composed of 1 protein: BovA.

Here is an example found in the RefSeq database:

The Borvo system in Enterobacter cloacae complex sp. ECL78 (GCF_019056615.1, NZ_CP077660) is composed of 1 protein: BovA (WP_126517459.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
2646127138] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T5 & SECphi4 & SECphi6 & SECphi18
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T5
        SECphi4
        SECphi6
        SECphi18
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none