Butters_gp57r

Description

The Butters_gp57r system is encoded in the Butters mycobacterium prophage and has been shown to inhibit rival phage replication YP_009304936.1.

Molecular Mechanism

Butters_gp57r is activated post-DNA injeciton and inhibits island3 and other phage DNA amplification. This system may inhibit heterotypic phage infeciton with the HEPN domain YP_009304936.1.

Example of genomic structure

The Butters_gp57r is composed of 1 protein: gp57r.

Here is an example found in the RefSeq database:

The Butters_gp57r system in Mycobacteroides immunogenum (GCF_001605725.1, NZ_CP011530) is composed of 1 protein: gp57r (WP_043080133.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Mohammed_2023[Mohammed et al., 2023] --> Origin_0
    Origin_0[Mycobacterium phage Butters 
YP_009304936.1] --> Expressed_0[Mycobacterium smegmatis mc2 155]
    Expressed_0[Mycobacterium smegmatis mc2 155] ----> Island3 & Brujita & Gyzlar & LHTSCC & Norz & PurpleHaze & Perplexer & Bud
    subgraph Title1[Reference]
        Mohammed_2023
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Island3
        Brujita
        Gyzlar
        LHTSCC
        Norz
        PurpleHaze
        Perplexer
        Bud
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none