Gao_Mza

Contributors: Hugo Vaysset

Description

Mza (MutL, Z1, DUF, AIPR) is a defense system composed of five proteins. Its antiphage activity was assessed by heterologous expression in E. coli against phages T2, T4, T5, lambda and M13 (ssDNA phage) (N/A) .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_Mza is composed of 5 proteins: MzaA, MzaB, MzaC, MzaD and MzaE.

Here is an example found in the RefSeq database:

gao_mza

The Gao_Mza system in Massilia sp. Se16.2.3 (GCF_014171595.1, NZ_CP050451) is composed of 6 proteins MzaA (WP_182990577.1) MzaB (WP_229425381.1) MzaC (WP_182990578.1) MzaD (WP_182990579.1) MzaE (WP_182990580.1) MzaE (WP_182990581.1)

Distribution of the system among prokaryotes

Structure

Experimental validation