Gao_Tmn

Contributors: Lucas Paoli, Chiara Gouviaux-Deletraz, Alexandre Roubaud

Description

The Gao_Tmn system is named after the first author of the first paper describing it (N/A) and contains the description of the gene identified: a transmembrane NTPase.

Tmn is a KAP NTPase, characterized by the presence of two transmembrane helices, a P-loop NTPase domain oriented towards the intracellular side, and a short periplasmic segment (N/A) .

Molecular mechanisms

As far as we are aware, the exact molecular mechanism is unknown. Gao-tmn can function independently or in synergy with other defense systems containing ATPase domains, such as Gabija or Septu I (N/A) . In these synergies, Gao-tmn seems to amplify ATPase signalling, resulting in a faster and stronger defense response.

Example of genomic structure

The Gao_Tmn is composed of 1 protein: TmnA.

Here is an example found in the RefSeq database:

gao_tmn

The Gao_Tmn system in Pectobacterium carotovorum (GCF_009931215.1, NZ_CP034237) is composed of 1 protein: TmnA (WP_161509209.1)

Distribution of the system among prokaryotes

Structure

Experimental validation