Paris
Description
PARIS (for Phage Anti-Restriction-Induced System) is a novel anti-phage system. It comprises an ATPase associated with a DUF4435 protein, which can be found either as a two-gene cassette or a single-gene fusion (N/A) .
Molecular mechanisms
This system relies on an unknown Abortive infection mechanism to trigger growth arrest upon sensing a phage-encoded protein (Ocr). Interestingly, the Ocr protein has been found to inhibit R-M systems and BREX systems, making PARIS a suitable defense mechanism against RM resistant and/or BREX resistant phages (N/A, N/A, N/A) .
Example of genomic structure
A total of 2 subsystems have been described for the Rst_PARIS system. The classical Paris is composed of two proteins AriA and AriB. The other type of Paris is the fused version with one AriAB protein.
Here is some examples found in the RefSeq database:
The PARIS_I system in Streptomyces sampsonii (GCF_001704195.1, NZ_CP016824) is composed of 2 proteins AriA_AAA15 (WP_079165307.1) AriB_DUF4435_I (WP_143067273.1)
The PARIS_I_merge system in Rhizobium sp. SL42 (GCF_021729845.1, NZ_CP063397) is composed of 1 protein: AAA_15_DUF4435 (WP_237370054.1)
Distribution of the system among prokaryotes
Structure
Group | Structure | Foldseek | System | Gene name | Subtype | Proteins in structure | System genes | Prediction type | N genes in sys | pLDDT | iptm+ptm | pDockQ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No data available | ||||||||||||