ShosTA
Description
ShosTA system was first described as a Toxin/Antitoxin system in 2012 (N/A) without demonstration of antiphase activity. In 2022, a paper described the same system as "DprA + PRTase" inside P2-like prophages and proved its antiphage activity. Finally, the antiphage activity was also proved in another study with the original name ShosTA (N/A) .
This system is composed of two proteins: ShosT and ShosA encoding for Hydrolase/PRTase and DprA (nucleotide binding) respectively.
Molecular mechanism
The ShosTA system is a toxin (ShosT) antitoxin (ShosA) system. The domains of ShosT (Hydrolase and PRTase) allow us to hypothesize toxicity linked to host protein degradation.
Example of genomic structure
The ShosTA is composed of 2 proteins: ShosA and ShosT.
Here is an example found in the RefSeq database:
The ShosTA system in Enterobacter cloacae (GCF_009707405.1, NZ_CP046116) is composed of 2 proteins ShosT (WP_129253192.1) ShosA (WP_129253194.1)