Defense Finder
Welcome on DefenseFinder's web page. On this site, you can freely use (without any login) the DefenseFinder webservice (see below) and get help to navigate the ever expanding world of defense systems. There is a collaborative knowledge base of defense systems that provide essential information on any given defense systems. You can further explore defense systems across all fully sequenced bacteria and get insight on the structure of each protein of those systems thanks to protein structure prediction using alphafold for monomer and dimers.
We encourage you to contribute to this knowledge database, and if you see any non up-to-date information, let us know, or contribute yourself
Defense Finder Webservice
Run Defense Finder analysis. It accepts both proteic and nucleic fasta files as inputs. The format is guessed automatically
A Run usually takes a couple of minutes. You can find your last run in the Analyses panel on the left.
Multiple analyses can be run at the same time, they can all be found in the Analyses panel.
Errors most often arise from incorrect input formats: make sure you are using a valid fasta file as input.
If you are using DefenseFinder please cite:
Systematic and quantitative view of the antiviral arsenal of prokaryotes
Tesson F., Hervé A. , Touchon M., d'Humières C., Cury J., Bernheim A., Nature Communication, 2022
MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes
Néron, B; Denise, R; Coluzzi, C; Touchon, M; Rocha, E.P.C.; Abby, S.S., Peer Community Journal, 2023
A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice, Wiki and Databases
Tesson, F., Planel, R., Egorov, A., Georjon, H., Vaysset, H., Brancotte, B., Néron, B., Mordret, E., Bernheim, A., Atkinson, G., & Cury, J., Preprint, 2024