Menshen

Description

The Menshen system has been identified by Millman et al. as a three-protein system NsnA, NsnB and NsnC. Menshen from Solibacillus silvestris StLB046 confers resistance in E. coli and B. subtilis against some phages (N/A) .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Menshen is composed of 3 proteins: NsnA, NsnB and NsnC.

Here is an example found in the RefSeq database:

The Menshen system in Streptomyces marincola (GCF_020410765.1, NZ_CP084541) is composed of 3 proteins NsnA (WP_226077564.1) NsnB (WP_226077566.1) NsnC_2507451963 (WP_226077568.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Solibacillus silvestris 
2562294789, 2562294790,
2562294791] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T6
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Solibacillus silvestris 
2562294789, 2562294790,
2562294791] --> Expressed_1[Bacillus subtilis]
    Expressed_1[Bacillus subtilis] ----> Fado
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        T2
        T4
        T6
        Fado
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none