MMB gp29-gp30
Description
MMB gp29-gp30 is a defense system that was found in the MichelleMyBell (MMB) temperate mycobacteriophage. It is an example of prophage-mediated defense (N/A) .
Molecular mechanisms
To the extent of our knowledge, the precise mechanism of action of MMB gp29-gp30 is not known. The system was shown to protect against lytic infection by temperate phage (e.g. phage Tweety) and does not act through abortive infection. Cells that survive infection tend to become lysogens for the infecting phage. It was also shown that the expression of gp29 alone was toxic in M. smegmatis (N/A) .
Example of genomic structure
The MMB_gp29_gp30 is composed of 2 proteins: gp29 and gp30.
Here is an example found in the RefSeq database:
The MMB_gp29_gp30 system in Mycolicibacterium insubricum (GCF_010731615.1, NZ_AP022618) is composed of 2 proteins gp29 (WP_234805905.1) gp30 (WP_083031848.1)