AbiR

Description

AbiR is a defense system discovered in 2000 (N/A) .

AbiR is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry (N/A) . AbiR is classified as abortive infection in (N/A) .

AbiR is composed of 3 genes: AbiRa, AbiRb, AbiRc. AbiRa encodes a sigma70 RNA polymerase subunit. AbiRb as homology with ParB nuclease domain according to HHpred. AbiRc has two different domains: an N_terminal PLD domain (PF13091) and at the C term an SNF2 DNA-dependent ATPase.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The AbiR is composed of 3 proteins: AbiRa, AbiRb and AbiRc.

Here is an example found in the RefSeq database:

The AbiR system in Clostridium perfringens (GCF_016027155.1, NZ_CP065677) is composed of 3 proteins AbiRc (WP_049039794.1) AbiRb (WP_049039795.1) AbiRa (WP_049039796.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Chopin_2005[Chopin et al., 2005] --> Origin_0
    Origin_0[lactococcal plasmid 
AAF75619.1, AAF75618.1,
AAF75617.1] --> Expressed_0[lactococci]
    Expressed_0[lactococci] ----> c2
    subgraph Title1[Reference]
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        c2
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none