AbiE

Contributors: Florian Tesson

Description

AbiE was discovered in 1995 on a Lactococcal plasmid (N/A) together with AbiF a homolog of AbiD](/defense-systems/abid).

AbiE is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry (N/A) . AbiE is classified as abortive infection in (N/A) .

AbiE is composed of two proteins: AbiEi and AbiEii. AbiEii is annotated as a nucleotidyltransferase.

Molecular mechanism

AbiE is a family of anti-phage defense systems. They act through a Toxin-Antitoxin mechanism, and are comprised of a pair of genes, with one gene being toxic while the other confers immunity to this toxicity (N/A) .

AbiEii is a GTP-binding nucleotidyltransferase (NTase) whose expression induces a reversible growth arrest (N/A) . On the other hand, AbiEi is a transcriptional autorepressor that binds to the promoter of the abiE operon. Based on these mechanisms, AbiE systems are classified as Type IV Toxin-Antitoxin systems, where the antitoxin and toxin are both proteins that do not directly interact with each other (N/A) .

Example of genomic structure

The AbiE is composed of 2 proteins: AbiEii and AbiEi.

Here is an example found in the RefSeq database:

The AbiE system in Halomonas piezotolerans (GCF_012427705.1, NZ_CP048602) is composed of 2 proteins AbiEi_3 (WP_231125510.1) AbiEii (WP_231125511.1)

Distribution of the system among prokaryotes

Among the NaN complete genomes of RefSeq, the AbiE is detected in NaN genomes (NaN %). The system was detected in NaN different species.
phylum
Percent genome having the system
0
100
Minimum genomes count to display

Structure

Summary
Group
Structure
Foldseek
System
Gene name
Subtype
Proteins in structure
System genes
Prediction type
N genes in sys
pLDDT
iptm+ptm
pDockQ
No data available
Items per page:
10
0-0 of 0

Experimental validation

      
graph LR;
    Chopin_2005[Chopin et al., 2005] --> Origin_0
    Origin_0[lactococcal plasmid 
AAB52382.1, AAB52383.1] --> Expressed_0[lactococci]
    Expressed_0[lactococci] ----> 936
    subgraph Title1[Reference]
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        936
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none
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AbiD
AbiG