Rst_2TM_1TM_TIR

Contributors: Alba Herrero del Valle

Description

The Rst_2TM_1TM_TIR system is carried by the P2-like phage AC1 and protects Escherichia coli C against lambda, LF82_P8 and P2 phages. This system is composed of three proteins, Rst_TIR_tm, which contains a TIR (Toll/interleukin-1 receptor) domain, Rst_1TM_TIR, which contains a transmembrane helix (TM) and Rst_2TM_TIR, that contains two TMs (N/A) . Rousset et al. suggested that the TIR-containing protein could generate a nucleotide messenger that in turn could activate the associated transmembrane proteins.

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Rst_2TM_1TM_TIR is composed of 3 proteins: Rst_2TM_TIR, Rst_TIR_tm and Rst_1TM_TIR.

Here is an example found in the RefSeq database:

The Rst_2TM_1TM_TIR system in Escherichia coli (GCF_004006575.1, NZ_CP034787) is composed of 3 proteins Rst_TIR_tm (WP_023140578.1) Rst_1TM_TIR (WP_001534953.1) Rst_2TM_TIR (WP_023140577.1)

Distribution of the system among prokaryotes

Among the NaN complete genomes of RefSeq, the Rst_2TM_1TM_TIR is detected in NaN genomes (NaN %). The system was detected in NaN different species.
phylum
Percent genome having the system
0
100
Minimum genomes count to display

Structure

Summary
Group
Structure
Foldseek
System
Gene name
Subtype
Proteins in structure
System genes
Prediction type
N genes in sys
pLDDT
iptm+ptm
pDockQ
No data available
Items per page:
10
0-0 of 0

Experimental validation

      
graph LR;
    Rousset_2022[Rousset et al., 2022] --> Origin_0
    Origin_0[Escherichia coli C
WP_001534952.1, WP_001534953.1, WP_001534955.1] --> Expressed_0[Escherichia coli C]
    Expressed_0[Escherichia coli C] ----> Lambda & LF82_P8 & P2 & SIAC10 & SID07 & DC1 & AC1
    subgraph Title1[Reference]
        Rousset_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Lambda
        LF82_P8
        P2
        SIAC10
        SID07
        DC1
        AC1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none
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