RosmerTA

Description

The RosmerTA system was found to have antiviral activity and was named after the Gallo-Roman goddess of fertility by Millman et al. 2022 (N/A) .

Molecular mechanisms

The RosmerTA system encodes a Zn-peptidase and a toxin of unknown function (N/A) . One toxin representative has been found to induce membrane depolarization (N/A) .

Example of genomic structure

The RosmerTA is composed of 2 proteins: RmrT and RmrA. The toxin can vary in sequence and structure.

Here is an example found in the RefSeq database:

The RosmerTA system in Paucibacter sp. KCTC 42545 (GCF_001477625.1, NZ_CP013692) is composed of 2 proteins RmrT_2662548665 (WP_231741552.1) RmrA_2662548665 (WP_058719324.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
2658042940, 2658042941] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> P1 & LambdaVir
    Ernits_2023[Ernits et al., 2023] --> Origin_1
    Origin_1[Gordonia phage Kita 
YP_009301394.1, YP_009301394.1] --> Expressed_1[Escherichia coli]
    Expressed_1[Escherichia coli] ----> Bas54 & Bas59
    subgraph Title1[Reference]
        Millman_2022
        Ernits_2023
end
    subgraph Title2[System origin]
        Origin_0
        Origin_1
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        P1
        LambdaVir
        Bas54
        Bas59
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none