RnlAB

Description

RnlAB is a type II toxin-antitoxin system, in which RnlA is the toxin and RnlB the antitoxin (N/A) .

Molecular mechanisms

The RnlA toxin has an RNase activity. RnlB (formerly yfjO) is the antitoxin and suppresses the RNase LS activity (N/A) .

Example of genomic structure

The RnlAB is composed of 2 proteins: RnlA and RnlB.

Here is an example found in the RefSeq database:

The RnlAB system in Bacteroides caecimuris (GCF_001688725.2, NZ_CP015401) is composed of 2 proteins RnlA (WP_004327332.1) RnlB (WP_004327330.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Koga_2011[Koga et al., 2011] --> Origin_0
    Origin_0[Escherichia coli] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T4
    subgraph Title1[Reference]
        Koga_2011
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T4
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none