Eleos

Description

\The Eleos (for the Greek goddess of mercy) system was previously described as the Dynamins-like system in (N/A) . It is formed by the LeoA and LeoBC proteins. LeoBC has been found to be analogous to GIMAPs (GTPases immunity-associated proteins), that are interferon-inducible (N/A) . LeoA in E. coli ETEC H10407 localizes to the periplasm and has been suggested to potentiate bacterial virulence. Its crystal structure has been solved (N/A) . Eleos from Bacillus vietnamensis NBRC 101237 has been found to protect against jumbo-phages in Bacillus subtilis (N/A) .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Eleos system is composed of 2 proteins: LeoA and, LeoBC. Sometimes, the system is in three genes: LeoA, LeoB and LeoC.

Here is an example found in the RefSeq database:

The Eleos system in Synechococcus sp. CBW1002 (GCF_015840915.1, NZ_CP060398) is composed of 2 proteins LeoBC (WP_197170386.1) LeoA (WP_197170387.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Bacillus vietnamensis 
2732656981, 2732656980] --> Expressed_0[Bacillus subtilis]
    Expressed_0[Bacillus subtilis] ----> AR9 & PBS1
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        AR9
        PBS1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none