Rst_DUF4238

Description

Rst_DUF4238 is a single gene system found in a screen of phage and phage-satellites antiviral hotspots (N/A) . It was shown to provide E.coli with a strong resistance against phage T7.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Rst_DUF4238 is composed of 1 protein: DUF4238.

Here is an example found in the RefSeq database:

The Rst_DUF4238 system in Novosphingobium pentaromativorans (GCF_000767465.1, NZ_CP009291) is composed of 1 protein: DUF4238_Pers (WP_007011908.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Rousset_2022[Rousset et al., 2022] --> Origin_0
    Origin_0[Escherichia coli P2 loci 
EGB68990.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T7
    subgraph Title1[Reference]
        Rousset_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T7
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none