Rst_gop_beta_cll

Contributors: Florian Tesson

Description

The gop-beta-cll system was shown to have an antiphage activity in 2022 (N/A) against Escherichia coli phage lambda and P1.

The gop-beta-cll was first described as a nonessential region of the bacteriophage P4 (N/A) .

This system is composed of 3 genes: gop, beta and cll.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

The production of the gop protein without beta is toxic (N/A) suggesting a toxin antitoxin mechanism (N/A) .

Example of genomic structure

The Rst_gop_beta_cll is composed of 3 proteins: beta, cll and gop.

Here is an example found in the RefSeq database:

The Rst_gop_beta_cll system in Klebsiella grimontii (GCF_019334465.1, NZ_CP079754) is composed of 3 proteins gop (WP_189095150.1) beta (WP_189095151.1) cll (WP_219192256.1)

Distribution of the system among prokaryotes

Among the NaN complete genomes of RefSeq, the Rst_gop_beta_cll is detected in NaN genomes (NaN %). The system was detected in NaN different species.
phylum
Percent genome having the system
0
100
Minimum genomes count to display

Structure

Summary
Group
Structure
Foldseek
System
Gene name
Subtype
Proteins in structure
System genes
Prediction type
N genes in sys
pLDDT
iptm+ptm
pDockQ
No data available

Experimental validation

      
graph LR;
    Rousset_2022[Rousset et al., 2022] --> Origin_0
    Origin_0[Enterobacteria phage P4 
WP_105493229.1, ENG39111.1,
NP_042032.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> Lambda & P1
    subgraph Title1[Reference]
        Rousset_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Lambda
        P1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none