RT-nitrilase-Tm
Description
RT-nitrilase-Tm (also named UG5-large) is a two-gene defense system. It was discovered from P4-like satellites in E. coli genomes (N/A) (N/A) . Its antiphage activity was shown in E. coli against phage AL505_P2 (Myoviridae).
The first protein is a reverse transcriptase (RT) fussed with C-N hydrolase domain (nitrilase); the second protein is transmembrane protein (N/A) .
The presence of an RT protein allows to draw a parallel between this system and DRT, AbiA, AbiK and AbiP2.
Molecular mechanism
As far as we are aware, the molecular mechanism is unknown.
Example of genomic structure
The Rst_RT-nitrilase-Tm is composed of 2 proteins: RT and RT-Tm.
Here is an example found in the RefSeq database:
The Rst_RT-Tm system in Morganella morganii (GCF_900478755.1, NZ_LS483498) is composed of 2 proteins RT (WP_061057569.1) RT-Tm (WP_004234654.1)