Rst_TIR-NLR
Description
The Rst_TIR-NLR system is named after the first author of the paper describing it (Rousset et al. 2022) and the domains of the only protein it contains (TIR, toll-interleukin-1 receptor, and NLR, nucleotide-binding leucine-rich repeat receptor) (N/A) .
This system is very similar to other bacterial defense systems: bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr), Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs).
Molecular mechanisms
As far as we are aware, the molecular mechanism is unknown. However, the molecular mechanism of closely related systems was previously studied. See bNACHT (https://defense-finder.pasteur.cloud/wiki/defense-systems/nlr), CARD_NLR (https://defense-finder.pasteur.cloud/wiki/defense-systems/card_nlr) and Avs (AVAST) (https://defense-finder.pasteur.cloud/wiki/defense-systems/avs)
Example of genomic structure
The Rst_TIR-NLR is composed of 1 protein: TIR.
Here is an example found in the RefSeq database:
The Rst_TIR-NLR system in Methylosinus sp. C49 (GCF_009936375.1, NZ_AP022332) is composed of 1 protein: TIR (WP_161914415.1)