SanaTA

Description

The SanaTA system is composed of 2 proteins: SanaT and, SanaA, where SanaT encodes a toxin and SanaA encodes an antitoxin to form a toxin-antitoxin (TA) system. The toxin protein, SanaT, contains a nucleotidyltransferase domain (PF08843). This system provides resistance against mutated T7 phages that lack the nonessential 4.5 gene in Shewanella sp. ANA-3. Sberro et al. showed that the defensiveness of sanaTA depends on the cleavage of SanaA by the Lon system, a protease that degrades the antitoxin to allow the activity of the toxin (N/A) .

Molecular mechanism

It has been shown to function as a toxin-antitoxin (TA) system.

Example of genomic structure

The SanaTA is composed of 2 proteins: SanaA and SanaT.

Here is an example found in the RefSeq database:

The SanaTA system in Euzebyella marina (GCF_003687485.1, NZ_CP032050) is composed of 2 proteins SanaA (WP_121848345.1) SanaT (WP_121848346.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Sberro_2013[Sberro et al., 2013] --> Origin_0
    Origin_0[Shewanella sp. ANA-3 
639720518, 639720519] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T7
    subgraph Title1[Reference]
        Sberro_2013
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T7
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none