SanaTA
Description
The SanaTA system is composed of 2 proteins: SanaT and, SanaA, where SanaT encodes a toxin and SanaA encodes an antitoxin to form a toxin-antitoxin (TA) system. The toxin protein, SanaT, contains a nucleotidyltransferase domain (PF08843). This system provides resistance against mutated T7 phages that lack the nonessential 4.5 gene in Shewanella sp. ANA-3. Sberro et al. showed that the defensiveness of sanaTA depends on the cleavage of SanaA by the Lon system, a protease that degrades the antitoxin to allow the activity of the toxin (N/A) .
Molecular mechanism
It has been shown to function as a toxin-antitoxin (TA) system.
Example of genomic structure
The SanaTA is composed of 2 proteins: SanaA and SanaT.
Here is an example found in the RefSeq database:
The SanaTA system in Euzebyella marina (GCF_003687485.1, NZ_CP032050) is composed of 2 proteins SanaA (WP_121848345.1) SanaT (WP_121848346.1)