AbiD

Description

AbiD is a single gene system discovered in May 1995 in the plasmid pBF61 of Lactococcus lactis (N/A) . An homolog of AbiD, named AbiD1 was discovered in July 1995 (N/A) .

AbiD is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry (N/A) . AbiR is classified as a possible abortive infection in (N/A) .

This antiphage defense system is very close to AbiD1 and AbiF (N/A) and is categorized as the same system. Furthermore, AbiD is also detected as the Abi2 system.

Molecular mechanism

For AbiD1 (N/A) (AAA79209), the expression of the protein is toxic to the bacteria and is therefore highly regulated. Expression of the protein is triggered by the orf1 of phage bIL66 which results in inhibition of the phage RuvC-like endonuclease activity and stops phage multiplication.

Example of genomic structure

The AbiD is composed of 1 protein: AbiD.

Here is an example found in the RefSeq database:

The AbiD system in Idiomarina sp. OT37-5b (GCF_002968395.1, NZ_CP027188) is composed of 1 protein: AbiD (WP_105307479.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Chopin_2005[Chopin et al., 2005] --> Origin_0
    Origin_0[lactococcal plasmid  
AAA63619.1] --> Expressed_0[lactococci]
    Expressed_0[lactococci] ----> 936 & c2 & P335
    subgraph Title1[Reference]
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        936
        c2
        P335
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none