Lit
Description
Lit was first identified in 1989 (N/A) , stands for late inhibitors of T4 and was found to inhibit phage T4 in Escherichia coli (K12). The Lit gene is found in the e14 cryptic prophage (N/A) . Lit is also partially active against other T-even phages (N/A) .
Molecular mechanisms
The Lit system detects cleaves EF-Tu translation factor (N/A) at a late stage of phage maturation, when the major capsid protein binds to EF-Tu and triggers its cleavage by Lit (N/A) . As a result, the translation is inhibited, which ultimately leads to cell death. Lit is part of the abortive infection category of defense systems.
Example of genomic structure
The Lit is composed of 1 protein: Lit.
Here is an example found in the RefSeq database:
The Lit system in Klebsiella pneumoniae (GCF_002180175.1, NZ_CP021686) is composed of 1 protein: Lit (WP_223861284.1)