BstA
Description
BstA is a family of defense systems. BtsA systems from Salmonella enterica subsp. enterica, Klebsiella pneumoniae and Escherichia coli have been shown to provide resistance against a large diversity of phages when expressed in a S. enterica or E.coli host (N/A) .
The majority of BstA systems appear to be prophage-encoded, as 79% of BstA homologs found in a set of Gram-negative bacterial genomes were associted with phage genes (N/A) .
Interestingly, part of the BstA locus appears to encode an anti-BstA genetic element (aba), which prevents auto-immunity for prophages encoding the BstA locus. The aba element appears to be specific to a given BstA locus, as replacing the aba element from a BstA locus with the aba element from another BstA system does not prevent auto-immunity (N/A) .
Molecular mechanism
The defense mechanism encoded by BstA remains to be elucidated. Experimental observation suggests that BtsA could act through an abortive infection mechanism. Fluorescence microscopy experiments suggest that the BstA protein colocalizes with phage DNA. The BstA protein appears to inhibit phage DNA replication during lytic phage infection cycles (N/A) .
Example of genomic structure
The BstA is composed of 1 protein: BstA.
Here is an example found in the RefSeq database:
The BstA system in Vibrio harveyi (GCF_021397735.1, NZ_CP090179) is composed of 1 protein: BstA (WP_038899043.1)
Distribution of the system among prokaryotes
Structure
Group | Structure | Foldseek | System | Gene name | Subtype | Proteins in structure | System genes | Prediction type | N genes in sys | pLDDT | iptm+ptm | pDockQ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No data available | ||||||||||||