PsyrTA
Description
Originally found in a high throughput shotgun cloning of bacterial fragments in E. coli looking for Toxin-Antitoxin pairs. PsyrTA is composed of two proteins, PsyrT, the toxin, is a RecQ family DNA helicase, and PsyrA, the antitoxin, was shown to be a Nucleotide-binding protein. Note that that system is sometimes called RqlHI (N/A) , where RqlH refers to PsyrT and RqlI to PsyrA.
Molecular mechanisms
from (N/A) :
The psyrT shares homology with domains of the RecQ helicase, a family of proteins implicated in DNA repair (Bernstein et al., 2010); and the antitoxin of the same system, psyrA, has a nucle- otide binding domain (COG0758) that was previously described in proteins involved in DNA uptake
from (N/A) :
Both systems encode an antitoxin with homology to DprA, a single-stranded DNA (ssDNA)-binding protein known to be involved in DNA transformation (Mortier- Barrière et al., 2007). The toxin contains a phosphoribosyl trans- ferase (PRTase) domain, which was previously found in effectors of retron abortive infection systems "
Example of genomic structure
The PsyrTA is composed of 2 proteins: PsyrA and PsyrT.
Here is an example found in the RefSeq database:
The PsyrTA system in Providencia rettgeri (GCF_013702265.1, NZ_CP059348) is composed of 2 proteins PsyrT (WP_049246657.1) PsyrA (WP_001103168.1)
Distribution of the system among prokaryotes
Structure
Group | Structure | Foldseek | System | Gene name | Subtype | Proteins in structure | System genes | Prediction type | N genes in sys | pLDDT | iptm+ptm | pDockQ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No data available | ||||||||||||