FS_GIY_YIG

Description

FS_GIY_YIG or GIY_YIG system was discovered in 2022 (N/A) inside the PICI KpCIXH209 in Klebsiella pneumoniae.

GIY_YIG is a single gene system that encodes for the GIY_YIG protein. The GIY_YIG protein contains the GIY YIG endonuclease domain.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown. The endonuclease domain suggests a nucleic acid degrading mechanism.

Example of genomic structure

The FS_GIY_YIG is composed of 1 protein: GIY_YIG.

Here is an example found in the RefSeq database:

The FS_GIY_YIG system in Klebsiella pneumoniae (GCF_021389995.1, NZ_CP089989) is composed of 1 protein: GIY_YIG (WP_053067640.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Fillol-Salom_2022[Fillol-Salom et al., 2022] --> Origin_0
    Origin_0[Klebsiella pneumoniae 
WP_071843248.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> HK97 & HK544
    Fillol-Salom_2022[Fillol-Salom et al., 2022] --> Origin_0
    Origin_0[Klebsiella pneumoniae 
WP_071843248.1] --> Expressed_1[Salmonella enterica]
    Expressed_1[Salmonella enterica] ----> P22 & BTP1
    subgraph Title1[Reference]
        Fillol-Salom_2022
end
    subgraph Title2[System origin]
        Origin_0
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        HK97
        HK544
        P22
        BTP1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none