CBASS
Description
The CBASS system stands for cyclic oligonucleotide-based antiphage signaling systems (N/A) . There are four types and multiple subtypes of characterized CBASS trans membrane systems. Activation of this system results in cell death to prevent phage replication. This system has a shared ancestry with the cGAS-STING innate immune pathway in animals (N/A)
Molecular mechanism
CBASS effector proteins limit phage propagation through membrane disruption. When CBASS is activated, Cap15 spreads throughout the cell and causes the inner membrane to rupture (N/A)
Example of genomic structure
A total of 4 subsystems have been described for the CBASS system.
Here are some examples found in the RefSeq database:
The CBASS_I system in Vibrio fluvialis (GCF_018140575.1, NZ_CP073273) is composed of 2 proteins Effector_4TM_S_4TM (WP_212571187.1) Cyclase_SMODS (WP_203534033.1)
The CBASS_II system in Klebsiella oxytoca (GCF_002072655.1, NZ_CP020358) is composed of 4 proteins Sensing_SAVED (WP_080528222.1) Jab (WP_071681958.1) AG_E1_ThiF (WP_080528223.1) Cyclase_II (WP_061351239.1)
The CBASS_III system in Conexibacter sp. DBS9H8 (GCF_023330685.1, NZ_CP097128) is composed of 5 proteins Sensing_SAVED (WP_249010498.1) Cyclase_II (WP_249010499.1) bacHORMA_2 (WP_249010500.1) HORMA (WP_249010501.1) TRIP13 (WP_249010502.1)
The CBASS_IV system in Flavobacterium alkalisoli (GCF_008000935.1, NZ_CP042831) is composed of 5 proteins OGG (WP_147582669.1) Cyclase_II (WP_147582670.1) TGT (WP_147582671.1) QueC (WP_147582672.1) Effector_2TM_Sa_NUDIX (WP_147582673.1)
Distribution of the system among prokaryotes
Structure
Group | Structure | Foldseek | System | Gene name | Subtype | Proteins in structure | System genes | Prediction type | N genes in sys | pLDDT | iptm+ptm | pDockQ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No data available | ||||||||||||