AbiP2

Description

AbiP2 system was discovered in 2006 inside a variable region of the P2-like coliphages (N/A) . This paper shows a relation with the known "Abi" system AbiK.

It was then proven to have an antiphage activity against T5 in E. coli (N/A) .

AbiP2 is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry (N/A) . AbiP2 is classified as possible abortive infection in (N/A) .

This system is called AbiP2 for the P2-like phage and has no relation with AbiP (a homolog of AbiC](/defense-systems/abic)).

However, with the discovery of dozens of new systems, it was categorized as one of the UG/Abi defense systems (N/A) along with DRT different subsystems, AbiA, AbiK and Rst_RT_Nitralase_TM.

Those systems are characterized by the presence of a reverse transcriptase domain of the "Unknown Group RT".

Molecular mechanism

To our knowledge, the molecular mechanism is unknown. Similarly, for the other systems of this family, the molecular mechanism remains unknown.

Example of genomic structure

The AbiP2 is composed of 1 protein: AbiP2.

Here is an example found in the RefSeq database:

The AbiP2 system in Halomonas alkaliphila (GCF_003612795.1, NZ_CP024811) is composed of 1 protein: AbiP2 (WP_120386816.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[ RT-Abi-P2
Escherichia coli  
WP_047657908.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T5
    Chopin_2005[Chopin et al., 2005] --> Origin_1
    Origin_1[lactococcal plasmid 
WP_045971693.1] --> Expressed_1[lactococci]
    Expressed_1[lactococci] ----> 936
    subgraph Title1[Reference]
        Gao_2020
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
        Origin_1
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        T5
        936
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none