Pif
Contributors: Lucas Paoli
Description
The Pif system (Phage Inhibition by F factors) was first described by Morisson & Malamy (N/A) . The Pif region of the F plasmid inhibits the phage T7 through abortive infection (N/A, N/A) .
Molecular mechanisms
PifA was later identified as the effector of the abortive infection (N/A, N/A) through nucleotide depletion by increased membrane permeability (also known as "leakage").
Example of genomic structure
The Pif is composed of 2 proteins: PifA and PifC.
Here is an example found in the RefSeq database:
The Pif system in Shigella flexneri (GCF_022353545.1, NZ_CP055168) is composed of 2 proteins PifC (WP_000952217.1) PifA (WP_000698737.1)