Olokun

Description

The system Olokun is composed of 2 genes OloA (Adaptin_N domain) and OloB (nuclease domain) of unknown function. This system was experimentally validated in Escherichia coli and protects against LambdaVir and SECphi27 infection.

The system is named after a revered deity of the Yoruba religion, associated with the deep sea and depicted as an enormously powerful figure. They are believed to possess immense wealth, are associated with health, fertility and prosperity, and are revered for their ability to induce profound transformation and renewal. They are frequently depicted as a mermaid or mermen, with both masculine and feminine aspects, reflecting the diversity and depth of the ocean.

Molecular mechanisms

To our knowledge, the molecular mechanism is unknown. Please update.

Example of genomic structure

The Olokun is composed of 2 proteins: OloA and OloB.

Here is an example found in the RefSeq database:

The Olokun system in Klebsiella quasipneumoniae (GCF_015286025.1, NZ_CP063902) is composed of 2 proteins OloA (WP_227667429.1) OloB (WP_194418165.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
2610314205, 2610314206] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> LambdaVir & SECphi27
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        LambdaVir
        SECphi27
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none