PD-T4-6

Description

The PD-T4-6 system is composed of a single protein. It was discovered via a selection screening of 71 E. coli strains challenged with diverse phage. The name stands from Phage Defense (PD) and the phage with which the strain was challenged (T4) (N/A) . The system has been identified as an Abortive Infection (Abi) system (N/A, N/A) . The protein was found within a P2-like prophage and contains a predicted Der/Thr kinase domain. Site-specific mutation in the domain reduces phage protection (N/A) .

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The PD-T4-6 is composed of 1 protein: PD-T4-6.

Here is an example found in the RefSeq database:

The PD-T4-6 system in Streptococcus ruminantium (GCF_021654555.1, NZ_AP025333) is composed of 1 protein: PD-T4-6 (WP_024532776.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
RRM76169.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T6
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
        T4
        T6
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none