Druantia

Contributors: Lucas Paoli

Description

The Druantia system was described by Doron et al. 2018 (N/A) and includes multiple subtypes, including type I (DruABCDE), type II (DruMFGE), and Type III (DruHE). Druantia is a particularly large system (~12 kb) and was named after the Gallic tree goddess. Type III was further tested by Wang et al. 2023 (N/A) .

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

A total of 3 subsystems have been described for the Druantia system.

Here is some examples found in the RefSeq database:

The Druantia_I system in Serratia fonticola (GCF_005489985.1, NZ_CP040182) is composed of 5 proteins DruA (WP_071682717.1) DruB (WP_071682718.1) DruC (WP_071682719.1) DruD (WP_071682720.1) DruE_1 (WP_071682721.1)

The Druantia_II system in Klebsiella michiganensis (GCF_018604105.1, NZ_CP075881) is composed of 4 proteins DruM (WP_045338337.1) DruF (WP_152403866.1) DruG (WP_214632470.1) DruE_2 (WP_152403875.1)

The Druantia_III system in Citrobacter werkmanii (GCF_002025225.1, NZ_CP019986) is composed of 2 proteins DruE_3 (WP_079225583.1) DruH (WP_079225584.1)

Distribution of the system among prokaryotes

Among the NaN complete genomes of RefSeq, the Druantia is detected in NaN genomes (NaN %). The system was detected in NaN different species.
phylum
Percent genome having the system
0
100
Minimum genomes count to display

Structure

Summary
Group
Structure
Foldseek
System
Gene name
Subtype
Proteins in structure
System genes
Prediction type
N genes in sys
pLDDT
iptm+ptm
pDockQ
No data available

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Doron_2018[Doron et al., 2018] --> Origin_0
    Origin_0[Escherichia coli 
ERA40829.1, ERA40830.1,
ERA40831.1, ERA40832.1,
ERA40833.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T5 & P1 & Lambda & T3 & T7 & PhiV-1 & Lambdavir & SECphi18 & SECphi27
    subgraph Title1[Reference]
        Gao_2020
        Doron_2018
end
    subgraph Title2[System origin]
        Origin_0
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
        T4
        T5
        P1
        Lambda
        T3
        T7
        PhiV-1
        Lambdavir
        SECphi18
        SECphi27
        T2
        T4
        T5
        P1
        Lambda
        T3
        T7
        PhiV-1
        Lambdavir
        SECphi18
        SECphi27
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none