PD-Lambda-3

Contributors: Héloïse Georjon

Description

PD-Lambda-3 systems were discovered to be anti-phage systems during an experimental screen performed on E.coli (N/A)

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The PD-Lambda-3 is composed of 2 proteins: PD-Lambda-3_A and PD-Lambda-3_B.

Here is an example found in the RefSeq database:

The PD-Lambda-3 system in Enterobacter sp. CRENT-193 (GCF_002787395.1, NZ_CP024812) is composed of 2 proteins PD-Lambda-3_A (WP_001542736.1) PD-Lambda-3_B (WP_039268887.1)

Distribution of the system among prokaryotes

Among the NaN complete genomes of RefSeq, the PD-Lambda-3 is detected in NaN genomes (NaN %). The system was detected in NaN different species.
phylum
Percent genome having the system
0
100
Minimum genomes count to display

Structure

Summary
Group
Structure
Foldseek
System
Gene name
Subtype
Proteins in structure
System genes
Prediction type
N genes in sys
pLDDT
iptm+ptm
pDockQ
No data available
Items per page:
10
0-0 of 0

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli 
RCP74640.1, RCP74641.1,
RCP74642.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> LambdaVir
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        LambdaVir
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none
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PD-Lambda-2
PD-Lambda-4