Stk2

Description

Eukaryotic-like serine/threonine kinases have a variety of functions in prokaryotes. Recently, a single-gene system (Stk2) encoding for a Serine/threonine kinase from Staphylococcus epidermidis has been found to have anti-phage activity both in its native host and in a heterologous S.aureus host (N/A) .

Molecular mechanism

Stk2 is an Abortive infection system, which triggers cell death upon phage infection, probably through phosphorylation of diverse essential cellular pathways (N/A) . Stk2 was shown to detect a phage protein named Pack, which was proposed to be involved in phage genome packaging (N/A) .

Example of genomic structure

The Stk2 is composed of 1 protein: Stk2.

Here is an example found in the RefSeq database:

The Stk2 system in Bacillus rugosus (GCF_023238245.1, NZ_CP096590) is composed of 1 protein: Stk2 (WP_248602500.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Depardieu_2016[Depardieu et al., 2016] --> Origin_0
    Origin_0[Staphylococcus epidermidis 
WP_001001347.1] --> Expressed_0[Staphylococcus epidermidis]
    Expressed_0[Staphylococcus epidermidis] ----> CNPx
    Depardieu_2016[Depardieu et al., 2016] --> Origin_0
    Origin_0[Staphylococcus epidermidis 
WP_001001347.1] --> Expressed_1[Staphylococcus aureus]
    Expressed_1[Staphylococcus aureus] ----> phage80alpha & phage85 & phiNM1 & phiNM2 & phiNM4
    subgraph Title1[Reference]
        Depardieu_2016
end
    subgraph Title2[System origin]
        Origin_0
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        CNPx
        phage80alpha
        phage85
        phiNM1
        phiNM2
        phiNM4
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none