Stk2
Description
Eukaryotic-like serine/threonine kinases have a variety of functions in prokaryotes. Recently, a single-gene system (Stk2) encoding for a Serine/threonine kinase from Staphylococcus epidermidis has been found to have anti-phage activity both in its native host and in a heterologous S.aureus host (N/A) .
Molecular mechanism
Stk2 is an Abortive infection system, which triggers cell death upon phage infection, probably through phosphorylation of diverse essential cellular pathways (N/A) . Stk2 was shown to detect a phage protein named Pack, which was proposed to be involved in phage genome packaging (N/A) .
Example of genomic structure
The Stk2 is composed of 1 protein: Stk2.
Here is an example found in the RefSeq database:
The Stk2 system in Bacillus rugosus (GCF_023238245.1, NZ_CP096590) is composed of 1 protein: Stk2 (WP_248602500.1)
Distribution of the system among prokaryotes
Structure
Group | Structure | Foldseek | System | Gene name | Subtype | Proteins in structure | System genes | Prediction type | N genes in sys | pLDDT | iptm+ptm | pDockQ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No data available | ||||||||||||