MqsRAC

Description

MqsRAC is a toxin-antitoxin-chaperone (TAC) system shown to have anti-phage activity.

Molecular mechanisms

As far as we are aware, the molecular mechanism of MqsRAC is unknown.

Example of genomic structure

The MqsRAC is composed of 2 proteins: mqsC and mqsR.

Here is an example found in the RefSeq database:

The MqsRAC system in Shigella dysenteriae (GCF_002949935.1, NZ_CP026827) is composed of 2 proteins mqsR (WP_024222007.1) mqsC (WP_157899945.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Vassallo_2022[Vassallo et al., 2022] --> Origin_0
    Origin_0[Escherichia coli strain C496_10 
WP_157899945.1, WP_021568457.1,
WP_024222007.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2
    subgraph Title1[Reference]
        Vassallo_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none