Tiamat

Description

This defense system is composed of one gene referred to as TmtA. This system is widespread across diverse prokaryotic phyla and was experimentally validated in Escherichia coli (confers protection against phages T6 and T5).

Molecular mechanism

To our knowledge the molecular mechanism is unknown. Please update.

Example of genomic structure

The Tiamat is composed of 1 protein: TmtA.

Here is an example found in the RefSeq database:

The Tiamat system in Undibacterium parvum (GCF_003955735.1, NZ_CP034464) is composed of 1 protein: TmtA (WP_126126601.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Bacillus cereus 
2641244160] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T6 & T5
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T6
        T5
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none