NLR / bNACHT

Description

This NLR like system is also known as the bNACHT systems.

Several proteins containing a NACHT module were found to have anti-phage activity. NACHT modules are also found in metazoans, where they play a role in innate immunity.

bNacht systems have some similarities with other defense systems: CARD_NLR , Rst_TIR-NLR, Avs.

Molecular mechanism

Bacterial NACHT module-containing proteins (bNACHT) encompass a C-terminal sensor, a central NACHT module, and N-terminal effector modules. The N-terminal effectors associated with bNACHT proteins are diverse, and include domains that have been previously described to be involved in other defense systems {doi=10.1016/j.cell.2023.04.015} As far as we are aware, the precise molecular mechanism of bNACHT is unknown.

Example of genomic structure

A total of 2 subsystems have been described for the NLR system.

Here is some examples found in the RefSeq database:

The NLR_like_bNACHT01 system in Colwellia sp. Arc7-D (GCF_003061515.1, NZ_CP028924) is composed of 1 protein: NLR_like_bNACHT01 (WP_162533747.1)

The NLR_like_bNACHT09 system in Parabacteroides johnsonii (GCF_020735865.1, NZ_CP085975) is composed of 1 protein: NLR_like_bNACHT09 (WP_009859882.1)

Distribution of the system among prokaryotes

Structure

Experimental validation

::