PD-Lambda-5
Contributors: Nathalie Bechon
Description
PD-lambda-5 is a two-gene system identified in a P2-like prophage. It encodes a protein with a nuclease and a HEPN domain, and a predicted methyltransferase. It confers broad anti-phage defense and does not seem to mediate abortive infection.
Molecular mechanism
PD-lambda-5 molecular mechanism has not been described to date. It confers protection against a broad range of phages and does not seem to be an abortive infection system.
Example of genomic structure
The PD-Lambda-5 is composed of 2 proteins: PD-Lambda-5_A and PD-Lambda-5_B.
Here is an example found in the RefSeq database:
The PD-Lambda-5 system in Plantactinospora sp. BB1 (GCF_003030385.1, NZ_CP028159) is composed of 2 proteins PD-Lambda-5_A (WP_159104731.1) PD-Lambda-5_B (WP_199853739.1)