AbiC

Contributors: Florian Tesson

Description

AbiC was discovered in Lactococcus lactis plasmid in 1992 ()

AbiC is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry () . AbiC is classified as abortive infection in () .

AbiC is a single gene system composed of the protein AbiC.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The AbiC is composed of 1 protein: AbiC.

Here is an example found in the RefSeq database:

The AbiC system in Cupriavidus pauculus (GCF_008693385.1, NZ_CP044066) is composed of 1 protein: AbiC (WP_150373977.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the AbiC is detected in 91 genomes (0.4 %).

The system was detected in 57 different species.

Proportion of genome encoding the AbiC system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

AbiC

Example 1

Experimental validation

      
graph LR;
    Fillol-Salom_2022[Fillol-Salom et al., 2022] --> Origin_0
    Origin_0[Klebsiella pneumoniae's  PICI KpCIFDAARGOS_1313 
QRS09118.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T5 & Lambda & HK97 & HK544 & HK578 & T7
    Fillol-Salom_2022[Fillol-Salom et al., 2022] --> Origin_0
    Origin_0[Klebsiella pneumoniae's  PICI KpCIFDAARGOS_1313 
QRS09118.1] --> Expressed_1[Salmonella enterica]
    Expressed_1[Salmonella enterica] ----> P22 & BTP1 & ES18
    Fillol-Salom_2022[Fillol-Salom et al., 2022] --> Origin_0
    Origin_0[Klebsiella pneumoniae's  PICI KpCIFDAARGOS_1313 
QRS09118.1] --> Expressed_2[Klebsiella pneumoniae]
    Expressed_2[Klebsiella pneumoniae] ----> Pokey & Raw & Eggy
    Chopin_2005[Chopin et al., 2005] --> Origin_1
    Origin_1[lactococcal plasmid 
AAA53569.1] --> Expressed_3[lactococci]
    Expressed_3[lactococci] ----> 936 & P335
    subgraph Title1[Reference]
        Fillol-Salom_2022
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
        Origin_0
        Origin_0
        Origin_1
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
        Expressed_2
        Expressed_3
end
    subgraph Title4[Protects against]
        T5
        Lambda
        HK97
        HK544
        HK578
        T7
        P22
        BTP1
        ES18
        Pokey
        Raw
        Eggy
        936
        P335
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1023/A:1002027321171
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10.1016/j.mib.2005.06.006
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10.1128/jb.174.22.7463-7469.1992
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10.1016/j.mib.2023.102312
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