AbiL

Contributors: Ernest Mordret

Description

AbiL was discovered in Lactococcus lactis. A plasmid containing the defense system was found to prevent infection by phage 712 through an abortive infection system

Molecular mechanism

Abortive infection. the PF13707 domain includes the RloB protein that is found within a bacterial restriction-modification operon. This family includes the AbiLii protein that is found as part of a plasmid-encoded phage abortive infection mechanism. Deletion within abiLii abolished the phage resistance. The family includes some proteins annotated as CRISPR Csm2 proteins.

Example of genomic structure

The AbiL is composed of 2 proteins: AbiLi and AbiLii.

Here is an example found in the RefSeq database:

The AbiL system in Sulfurimonas sp. SWIR-19 (GCF_020410885.1, NZ_CP084578) is composed of 2 proteins AbiLi2 (WP_226066409.1) AbiLii2 (WP_226066410.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the AbiL is detected in 188 genomes (0.82 %).

The system was detected in 126 different species.

Proportion of genome encoding the AbiL system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

AbiL

Example 1

Experimental validation

      
graph LR;
    Chopin_2005[Chopin et al., 2005] --> Origin_0
    Origin_0[lactococcal plasmid 
AAB53710.1, AAB53711.1] --> Expressed_0[lactococci ]
    Expressed_0[lactococci ] ----> 936 & c2
    subgraph Title1[Reference]
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        936
        c2
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1111/j.1574-6968.1997.tb10185.x
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10.1016/j.mib.2005.06.006
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