AbiT

Contributors: Florian Tesson

Description

AbiT was discovered in Lactococcus lactis in 2022 () .

AbiT is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry () . Even though, their name corresponds to abortive infection, their mechanism of action does not necessarily correspond to an abortive infection phenotype. AbiT is classified as an abortive infection in () .

AbiT is composed of two proteins: AbiTi with a transmembrane helix domain and AbiTii.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The AbiT is composed of 2 proteins: AbiTi and AbiTii.

Here is an example found in the RefSeq database:

The AbiT system in Bdellovibrio bacteriovorus (GCF_000317895.1, NC_019567) is composed of 2 proteins AbiTii (WP_051026283.1) AbiTi (WP_041577337.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the AbiT is detected in 8 genomes (0.04 %).

The system was detected in 6 different species.

Proportion of genome encoding the AbiT system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

AbiT

Example 1

Experimental validation

      
graph LR;
    Chopin_2005[Chopin et al., 2005] --> Origin_0
    Origin_0[lactococcal plasmid 
AAN60762.1, AAN60763.1] --> Expressed_0[lactococci]
    Expressed_0[lactococci] ----> 936 & P335
    subgraph Title1[Reference]
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        936
        P335
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1023/A:1002027321171
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10.1016/j.mib.2005.06.006
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10.1128/jb.184.22.6325-6332.2002
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10.1016/j.mib.2023.102312
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