AbiU

Contributors: Nathalie Bechon

Description

AbiU is a single-protein abortive infection defense system described in Lactococcus.

Molecular mechanism

The molecular mechanism of AbiU is not well understood. It was shown that cells expressing AbiU showed delayed transcription of phage DNA, although how it is achieved, or how it protects the bacterial culture is not understood. AbiU was shown to be encoded near another gene that seems to be an inhibitor of defense () .

Example of genomic structure

The AbiU is composed of 1 protein: AbiU.

Here is an example found in the RefSeq database:

The AbiU system in Bacillus subtilis (GCF_001889385.1, NZ_CP018295) is composed of 1 protein: AbiU (WP_072589761.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the AbiU is detected in 950 genomes (4.17 %).

The system was detected in 389 different species.

Proportion of genome encoding the AbiU system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

AbiU

Example 1

Experimental validation

      
graph LR;
    Chopin_2005[Chopin et al., 2005] --> Origin_0
    Origin_0[lactococcal plasmid 
AAG17058.] --> Expressed_0[lactococci]
    Expressed_0[lactococci] ----> 936 & c2 & P335
    subgraph Title1[Reference]
        Chopin_2005
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        936
        c2
        P335
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1023/A:1002027321171
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10.1016/j.mib.2005.06.006
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10.1128/AEM.67.11.5225-5232.2001
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