AbiV

Contributors: Florian Tesson

Description

AbiV was discovered was discovered in 2008 in Lactococcus lactis ref:{doi=10.1023/A:1002027321171}.

AbiO is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry () . Even though their name corresponds to an abortive infection, their mechanism of action does not necessarily correspond to an abortive infection. AbiV system is classified as an abortive infection in ()

This system is composed of one single protein containing a HEPN domain (HEPN_AbiV PF18728).

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The AbiV is composed of 1 protein: AbiV.

Here is an example found in the RefSeq database:

The AbiV system in Bacillus mycoides (GCF_018739365.1, NZ_CP035984) is composed of 1 protein: AbiV (WP_070128168.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the AbiV is detected in 97 genomes (0.43 %).

The system was detected in 61 different species.

Proportion of genome encoding the AbiV system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

AbiV

Example 1

Experimental validation

      
graph LR;
    Haaber_2008[Haaber et al., 2008] --> Origin_0
    Origin_0[Lactococcus lactis 
AAK16428.1] --> Expressed_0[Lactococcus lactis]
    Expressed_0[Lactococcus lactis] ----> sk1 & p2 & jj50 & P008 & bIL170 & c2 & bIL67 & ml3 & eb1
    subgraph Title1[Reference]
        Haaber_2008
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        sk1
        p2
        jj50
        P008
        bIL170
        c2
        bIL67
        ml3
        eb1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1023/A:1002027321171
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10.1128/AEM.00780-08
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10.1016/j.mib.2005.06.006
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10.1016/j.mib.2023.102312
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