AbiZ

Contributors: Florian Tesson

Description

AbiZ was discovered in 2006 on a Lactococcus lactis conjugative plasmid pTR2030 () .

AbiZ is one of the so-called "Abi" systems for "Abortive infection" discovered in the 90's in research related to the dairy industry () . AbiZ is classified as abortive infection in () .

AbiZ is composed of a single protein AbiZ.

Molecular mechanism

AbiZ acts as an abortive infection system. AbiZ proteins sense holins and lysins from the infecting bacteriophage and use them to induce premature cell lysis (, ) .

Example of genomic structure

The AbiZ is composed of 1 protein: AbiZ.

Here is an example found in the RefSeq database:

The AbiZ system in Fusobacterium pseudoperiodonticum (GCF_002763695.1, NZ_CP024700) is composed of 1 protein: AbiZ (WP_099987858.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the AbiZ is detected in 118 genomes (0.52 %).

The system was detected in 97 different species.

Proportion of genome encoding the AbiZ system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

AbiZ

Example 1

Experimental validation

      
graph LR;
    Durmaz_2007[Durmaz and  Klaenhammer, 2007] --> Origin_0
    Origin_0[Lactococcus lactis 
ABI93964.1] --> Expressed_0[Lactococcus lactis]
    Expressed_0[Lactococcus lactis] ----> Phi31.2 & ul36 & phi31 & phi48 & phi31.1 & Q30 & Q36 & Q33 & phi50 & phi48
    subgraph Title1[Reference]
        Durmaz_2007
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Phi31.2
        ul36
        phi31
        phi48
        phi31.1
        Q30
        Q36
        Q33
        phi50
        phi48
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1023/A:1002027321171
no authors
no containerTitle ()
10.1128/JB.00904-06
no authors
no containerTitle ()
10.1016/j.mib.2005.06.006
no authors
no containerTitle ()
10.1016/j.mib.2023.102312
no authors
no containerTitle ()
10.1146/annurev-virology-011620-040628
no authors
no containerTitle ()