Dodola

Contributors: Ernest Mordret

Description

Dodola is named after a figure from Slavic mythology, often associated with rain and fertility. The Dodola defense system was first discovered through its common association with known defense systems, and characterized in B. subtilis, demonstrating its efficacy against the SPP1 phage () . Dodola is composed of two proteins, DolA and DolB. DolA contains a DUF6414 domain, and DolB contains a ClpB-like domain.

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Dodola is composed of 2 proteins: DolA and DolB.

Here is an example found in the RefSeq database:

The Dodola system in Lacrimispora saccharolytica (GCF_000144625.1, NC_014376) is composed of 2 proteins DolA (WP_012104148.1) DolB (WP_012104147.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Dodola is detected in 312 genomes (1.37 %).

The system was detected in 91 different species.

Proportion of genome encoding the Dodola system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Dodola

Example 1

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Bacillus cereus 
2625022793, 2625022793] --> Expressed_0[Bacillus subtilis]
    Expressed_0[Bacillus subtilis] ----> SPP1
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        SPP1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.09.017
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