Dsr

Example of genomic structure

A total of 2 subsystems have been described for the Dsr system.

Here are some examples found in the RefSeq database:

The Dsr_I system in Pseudohalocynthiibacter aestuariivivens (GCF_011040495.1, NZ_CP049037) is composed of 1 protein: Dsr1 (WP_165194530.1)

The Dsr_II system in Deinococcus deserti (GCF_000020685.1, NC_012526) is composed of 1 protein: Dsr2 (WP_083764220.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Dsr is detected in 246 genomes (1.08 %).

The system was detected in 162 different species.

Proportion of genome encoding the Dsr system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Dsr_I

Example 1

Dsr_II

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[ DSR1
Escherichia coli 
WP_029488749.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T3 & T7 & PhiV-1
    Gao_2020[Gao et al., 2020] --> Origin_1
    Origin_1[ DSR2
Cronobacter sakazakii 
WP_015387030.1] --> Expressed_1[Escherichia coli]
    Expressed_1[Escherichia coli] ----> Lambda
    Garb_2022[Garb et al., 2022] --> Origin_2
    Origin_2[ DSR2
Bacillus subtilis 
WP_029317421.1] --> Expressed_2[Bacillus subtilis ]
    Expressed_2[Bacillus subtilis ] ----> SPR
    Garb_2022[Garb et al., 2022] --> Origin_3
    Origin_3[ DSR1
Bacillus subtilis 
WP_053564071.1] --> Expressed_3[Bacillus subtilis]
    Expressed_3[Bacillus subtilis] ----> phi29
    subgraph Title1[Reference]
        Gao_2020
        Garb_2022
end
    subgraph Title2[System origin]
        Origin_0
        Origin_1
        Origin_2
        Origin_3
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
        Expressed_2
        Expressed_3
end
    subgraph Title4[Protects against]
        T3
        T7
        PhiV-1
        Lambda
        SPR
        phi29
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1038/s41564-022-01207-8
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10.1126/science.aba0372
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