Eleos

Contributors: Alba Herrero del Valle

Description

\The Eleos (for the Greek goddess of mercy) system was previously described as the Dynamins-like system in () . It is formed by the LeoA and LeoBC proteins. LeoBC has been found to be analogous to GIMAPs (GTPases immunity-associated proteins), that are interferon-inducible () . LeoA in E. coli ETEC H10407 localizes to the periplasm and has been suggested to potentiate bacterial virulence. Its crystal structure has been solved () . Eleos from Bacillus vietnamensis NBRC 101237 has been found to protect against jumbo-phages in Bacillus subtilis () .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Eleos system is composed of 2 proteins: LeoA and, LeoBC. Sometimes, the system is in three genes: LeoA, LeoB and LeoC.

Here is an example found in the RefSeq database:

The Eleos system in Synechococcus sp. CBW1002 (GCF_015840915.1, NZ_CP060398) is composed of 2 proteins LeoBC (WP_197170386.1) LeoA (WP_197170387.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Eleos is detected in 414 genomes (1.82 %).

The system was detected in 223 different species.

Proportion of genome encoding the Eleos system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Experimentaly determined structure

From () in Escherichia coli (ETEC) strain H10407:

Eleos

Example 1

Experimental validation

      
graph LR;
    Millman_2022[Millman et al., 2022] --> Origin_0
    Origin_0[Bacillus vietnamensis 
2732656981, 2732656980] --> Expressed_0[Bacillus subtilis]
    Expressed_0[Bacillus subtilis] ----> AR9 & PBS1
    subgraph Title1[Reference]
        Millman_2022
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        AR9
        PBS1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1016/j.chom.2022.09.017
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10.1101/2022.12.12.520048
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10.1371/journal.pone.0107211
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