ApeA

Contributors: Hugo Vaysset

Description

ApeA is a defense system composed of one protein, initially described as a member of the HEPN superfamily which groups proteins with nucleotide binding activity (CL0291).

ApeA is predicted to act via an abortive infection mechanism.

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_Ape is composed of 1 protein: ApeA.

Here is an example found in the RefSeq database:

The Gao_Ape system in Enterobacter mori (GCF_018638795.1, NZ_CP071064) is composed of 1 protein: ApeA (WP_215231222.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_Ape is detected in 76 genomes (0.33 %).

The system was detected in 45 different species.

Proportion of genome encoding the Gao_Ape system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Gao_Ape

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[Escherichia coli 
WP_000706972.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> T2 & T4 & T5 & T3 & T7 & PhiV-1
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        T2
        T4
        T5
        T3
        T7
        PhiV-1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
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10.1186/1745-6150-8-15
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