Gao_Her

Contributors: To do

Example of genomic structure

A total of 2 subsystems have been described for the Gao_Her system.

Here are some examples found in the RefSeq database:

The Gao_Her_DUF system in Escherichia coli (GCF_023657935.1, NZ_CP098183) is composed of 2 proteins DUF4297 (WP_064484828.1) HerA_DUF (WP_064484829.1)

The Gao_Her_SIR system in Xanthomonas citri (GCF_018831325.1, NZ_CP029270) is composed of 2 proteins SIR2 (WP_046831681.1) HerA_SIR2 (WP_046831680.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_Her is detected in 231 genomes (1.01 %).

The system was detected in 134 different species.

Proportion of genome encoding the Gao_Her system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Experimentaly determined structure

From () in Escherichia coli:

From () in Escherichia coli:

Gao_Her_DUF

Example 1

Gao_Her_SIR

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[ SIR2 + HerA
Escherichia coli 
WP_021577682.1, WP_021577683.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> Lambda & T3 & T7 & PhiV-1
    Gao_2020[Gao et al., 2020] --> Origin_1
    Origin_1[ DUF4297 + HerA
Escherichia coli 
WP_016239655.1, WP_016239654.1] --> Expressed_1[Escherichia coli]
    Expressed_1[Escherichia coli] ----> T4 & P1 & Lambda & T3 & T7
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
        Origin_1
end
    subgraph Title3[Expression species]
        Expressed_0
        Expressed_1
end
    subgraph Title4[Protects against]
        Lambda
        T3
        T7
        PhiV-1
        T4
        P1
        Lambda
        T3
        T7
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
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10.1016/j.molcel.2023.11.007
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10.1016/j.molcel.2023.11.010
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