Gao_Hhe

Contributors: Marian Dominguez-Mirazo

Description

The Gao_hhe system is composed of a single protein. It was predicted through a guilty-by-association approach independent of domain annotations and validated in a heterologous system () . It contains a predicted helicase and a Vsr (very short patch repair) endonuclease domain (, ) .

Molecular mechanisms

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_Hhe is composed of 1 protein: HheA.

Here is an example found in the RefSeq database:

The Gao_Hhe system in Thioalkalivibrio paradoxus (GCF_000227685.2, NZ_CP007029) is composed of 1 protein: HheA (WP_006745815.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_Hhe is detected in 276 genomes (1.21 %).

The system was detected in 56 different species.

Proportion of genome encoding the Gao_Hhe system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Gao_Hhe

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[Escherichia coli 
WP_032200272.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> Lambda & T3 & T7 & PhiV-1
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Lambda
        T3
        T7
        PhiV-1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
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10.1093/nar/gkad317
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10.1128/jvi.00599-23
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