Gao_Iet

Description

Gao_Iet or Iet or IetAS was discovered in 2020 among other defense systems by () .

The Iet system is composed of two proteins: IetA (an ATPase) and IetS (a protease) () .

Molecular mechanism

As far as we are aware, the molecular mechanism is unknown.

Example of genomic structure

The Gao_Iet is composed of 2 proteins: IetA and IetS.

Here is an example found in the RefSeq database:

The Gao_Iet system in Salmonella sp. SJTUF14076 (GCF_015534835.1, NZ_CP064674) is composed of 2 proteins IetA (WP_023226994.1) IetS (WP_024148175.1)

Distribution of the system among prokaryotes

Among the 22,803 complete genomes of RefSeq, the Gao_Iet is detected in 389 genomes (1.71 %).

The system was detected in 185 different species.

Proportion of genome encoding the Gao_Iet system for the 14 phyla with more than 50 genomes in the RefSeq database.

Structure

Gao_Iet

Example 1

Experimental validation

      
graph LR;
    Gao_2020[Gao et al., 2020] --> Origin_0
    Origin_0[Escherichia coli 
WP_000385105.1, WP_001551050.1] --> Expressed_0[Escherichia coli]
    Expressed_0[Escherichia coli] ----> Lambda & T3 & T7 & PhiV-1
    subgraph Title1[Reference]
        Gao_2020
end
    subgraph Title2[System origin]
        Origin_0
end
    subgraph Title3[Expression species]
        Expressed_0
end
    subgraph Title4[Protects against]
        Lambda
        T3
        T7
        PhiV-1
end
    style Title1 fill:none,stroke:none,stroke-width:none
    style Title2 fill:none,stroke:none,stroke-width:none
    style Title3 fill:none,stroke:none,stroke-width:none
    style Title4 fill:none,stroke:none,stroke-width:none

    

References

10.1126/science.aba0372
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